Hybrids are a magical species that are a combination of two different species. Hybridization is most commonly caused through reproduction. These hybrids possess both the strengths and some of the weaknesses of their parent races, along with powerful attributes unique to themselves alone due to their combined heritage. It is typical that these hybrids will inherit powers from one or both magical parents and may develop unique hybrid powers, such as Electrokinetic Orbing.
- Main article: Whitelighter-Witches
Whitelighter-Witches are a cross between a witch and a Whitelighter. A romantic relationship between a witch and a Whitelighter was forbidden by the Elders, and, for this reason, these hybrids are viewed as abominations. The first of this breed shown was Jada Shields. Jada was born to an unnamed witch and Whitelighter and was adopted by a human couple. At some point, she ran away from home due to her coming into her powers and was saved by the Sarcana.
- Main article: Half-Demons
Half-Demons are a cross between a mortal and a demon. These hybrids are capable of experiencing emotions such as love, unlike pure-blooded demons. This can sway them to the side of good, even if the pull of evil is great. Some demons intentionally create hybrids by mating with mortals for various selfish purposes. The first of this breed shown was Parker Caine. Parker is the son of the demon Alastor and the mortal Julia Wagner. Since he is a demon born of a human, Parker is a potential candidate to become the host for The Source of All Evil. Therefore, Parker's father wanted to release the Source so that Parker could host him, making their family the most powerful in The Underworld.
- Main article: Demon-Witches
Demon-Witches are a cross between a witch and a demon. For this reason, they possess powers of both demons and witches. The first known of this breed shown was Abigael Jameson-Caine. She is the daughter of the demon, Alastor, and an unknown witch. Due to being a female, she was looked at as an abomination by her demonic family and was raised by her mother. She was saved by Macy Vaughn in San Francisco from a group of demons.
Due to the circumstances of her resurrection, Macy Vaughn had demonic blood flowing through her veins which provided her with demonic powers. This made her a nonhereditary hybrid. However, in an effort to restore the Power of Three, she had her demonic powers stripped by Abigael.